Otranto (Italian pronunciation: [ˈɔːtranto]; Latin: Hydruntum) is a town and comune in the province of Lecce (Apulia, Italy), in a fertile region once famous for its breed of horses.

It is located on the east coast of the Salento peninsula. The Strait of Otranto, to which the city gives its name, connects the Adriatic Sea with the Ionian Sea and separates Italy from Albania. The harbour is small and has little trade.